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1

Design and Synthesis of Potent Inhibitors of the Malaria Aspartyl Proteases Plasmepsin I and II. Use of Solid-Phase Synthesis to Explore Novel Statine Motifs

Johansson, Per-Ola, Chen, Yantao, Belfrage, Anna Karin, Blackman, Michael J., Kvarnström, Ingemar, Jansson, Katarina, Vrang, Lotta, Hamelink, Elizabeth, Hallberg, Anders, Rosenquist, Åsa

Journal:

Journal of Medicinal Chemistry

Year:

2004

Language:

english

File:

PDF, 481 KB

english, 2004

2

Synthesis of Enantiomerically Pure Bis(hydroxymethyl)-Branched Cyclohexenyl and Cyclohexyl Purines as Potential Inhibitors of HIV

Rosenquist, Åsa, Kvarnström, Ingemar, Classon, Björn, Samuelsson, Bertil

Journal:

Journal of Organic Chemistry

Year:

1996

Language:

english

File:

PDF, 297 KB

english, 1996

3

Design, synthesis and SAR of potent statine-based BACE-1 inhibitors: Exploration of P1 phenoxy and benzyloxy residues

Marcus Bäck, Jonas Nyhlén, Ingemar Kvarnström, Sara Appelgren, Neera Borkakoti, Katarina Jansson, Jimmy Lindberg, Susanne Nyström, Anders Hallberg, Åsa Rosenquist, Bertil Samuelsson

Journal:

Bioorganic & Medicinal Chemistry

Year:

2008

Language:

english

File:

PDF, 419 KB

english, 2008

4

Impact of the Central Hydroxyl Groups on the Activity of Symmetrical HIV-1 Protease Inhibitors Derived From l-Mannaric Acid

Johanna Wachtmeister, Anna Mühlman, Björn Classon, Ingemar Kvarnström, Anders Hallberg, Bertil Samuelsson

Journal:

Year:

2000

Language:

english

File:

PDF, 139 KB

english, 2000

5

Solid-phase library synthesis of reversed-statine type inhibitors of the malarial aspartyl proteases plasmepsin I and II

Anders Dahlgren, Ingemar Kvarnström, Lotta Vrang, Elizabeth Hamelink, Anders Hallberg, Åsa Rosenquist, Bertil Samuelsson

Journal:

Bioorganic & Medicinal Chemistry

Year:

2003

Language:

english

File:

PDF, 402 KB

english, 2003

6

Design and Synthesis of New Potent C 2 -Symmetric HIV-1 Protease Inhibitors. Use of l -Mannaric Acid as a Peptidomimetic Scaffold

Alterman, Mathias, Björsne, Magnus, Mühlman, Anna, Classon, Björn, Kvarnström, Ingemar, Danielson, Helena, Markgren, Per-Olof, Nillroth, Ulrika, Unge, Torsten, Hallberg, Anders, Samuelsson, Bertil

Journal:

Journal of Medicinal Chemistry

Year:

1998

Language:

english

File:

PDF, 301 KB

english, 1998

7

Synthesis of novel potent hepatitis C virus NS3 protease inhibitors: Discovery of 4-hydroxy-cyclopent-2-ene-1,2-dicarboxylic acid as a N-acyl-l-hydroxyproline bioisostere

Fredrik Thorstensson, Fredrik Wångsell, Ingemar Kvarnström, Lotta Vrang, Elizabeth Hamelink, Katarina Jansson, Anders Hallberg, Åsa Rosenquist, Bertil Samuelsson

Journal:

Bioorganic & Medicinal Chemistry

Year:

2007

Language:

english

File:

PDF, 679 KB

english, 2007

8

Cyclic HIV-1 Protease Inhibitors Derived from Mannitol: Synthesis, Inhibitory Potencies, and Computational Predictions of Binding Affinities

Hultén, Johan, Bonham, Nicholas M., Nillroth, Ulrika, Hansson, Tomas, Zuccarello, Guido, Bouzide, Abderrahim, Åqvist, Johan, Classon, Björn, Danielson, U. Helena, Karlén, Anders, Kvarnström, Ingemar,

Journal:

Journal of Medicinal Chemistry

Year:

1997

Language:

english

File:

PDF, 388 KB

english, 1997

9

New Proline Mimetics: Synthesis of Thrombin Inhibitors Incorporating Cyclopentane- and Cyclopentenedicarboxylic Acid Templates in the P2 Position. Binding Conformation Investigated by X-ray Crystallography

Nöteberg, Daniel, Brånalt, Jonas, Kvarnström, Ingemar, Linschoten, Marcel, Musil, Djordje, Nyström, Jan-Erik, Zuccarello, Guido, Samuelsson, Bertil

Journal:

Journal of Medicinal Chemistry

Year:

2000

Language:

english

File:

PDF, 299 KB

english, 2000

10

Preparation and N.M.R. studies of pyruvic acid and related acetals of pyranosides: configuration at the acetal carbon atoms

Per J. Garegg, Bengt Lindberg, Ingemar Kvarnström

Journal:

Carbohydrate Research

Year:

1979

Language:

english

File:

PDF, 557 KB

english, 1979

11

Synthesis of [4,5-Bis(hydroxymethyl)-1,3-dioxolan-2-yl]nucleosides as Potential Inhibitors of HIV

Brånalt, Jonas, Kvarnström, Ingemar, Classon, Björn, Samuelsson, Bertil

Journal:

Journal of Organic Chemistry

Year:

1996

Language:

english

File:

PDF, 267 KB

english, 1996

12

Synthesis of 1d- and 1l-4-O-benzyl-myo-inositol, 1d-4-O-α-l-fucopyranosyl-myo-inositol (identical to a natural glycoside), and 1l-4-O-α-l-fucopyranosyl-myo-inositol

Per J. Garegg, Bengt Lindberg, Ingemar Kvarnström, Stefan C.T. Svensson

Journal:

Carbohydrate Research

Year:

1985

Language:

english

File:

PDF, 427 KB

english, 1985

13

Potent inhibitors of the hepatitis C virus NS3 protease: Use of a novel P2 cyclopentane-derived template

Per-Ola Johansson, Marcus Bäck, Ingemar Kvarnström, Katarina Jansson, Lotta Vrang, Elizabeth Hamelink, Anders Hallberg, Åsa Rosenquist, Bertil Samuelsson

Journal:

Bioorganic & Medicinal Chemistry

Year:

2006

Language:

english

File:

PDF, 378 KB

english, 2006

14

Solid-Phase Synthesis of Libraries Generated from a 4-Phenyl-2-carboxy-piperazine Scaffold†

Nilsson, Jonas W., Thorstensson, Fredrik, Kvarnström, Ingemar, Oprea, Tudor, Samuelsson, Bertil, Nilsson, Ingemar

Journal:

Journal of Combinatorial Chemistry

Year:

2001

Language:

english

File:

PDF, 79 KB

english, 2001

15

Synthesis and Anti-viral Properties of 2',3'-Dideoxy-3',4'-dihydroxymethyl Substituted Pyrimidine Nucleoside Analogues

Björsne, Magnus, Classon, Björn, Kers, Inger, Samuelsson, Bertil, Kvarnström, Ingemar

Journal:

Nucleosides Nucleotides & Nucleic Acids

Year:

1995

Language:

english

File:

PDF, 202 KB

english, 1995

16

Synthesis of [4,5-Bis(hydroxymethyl)-1,3-oxathiolan-2-yl]nucleosides as Potential Inhibitors of HIV via Stereospecific Base-Induced Rearrangement of a 2,3-Epoxy Thioacetate 1

Brånalt, Jonas, Kvarnström, Ingemar, Classon, Björn, Samuelsson, Bertil

Journal:

Journal of Organic Chemistry

Year:

1996

Language:

english

File:

PDF, 349 KB

english, 1996

17

Pictet–Spengler reaction of biogenic amines with carbohydrates. Synthesis of novel C -nucleosides

Piper, Ian M., MacLean, David B., Kvarnstrôm, Ingemar, Szarek, Walter A.

Journal:

Canadian Journal of Chemistry

Year:

1983

Language:

english

File:

PDF, 421 KB

english, 1983

18

A convenient synthesis of 1-(S)-[1′-(S)-(t-butyloxycarbonylamino)-2′-phenylethyl]oxirane. A useful building block in the synthesis of HIV protease inhibitors

Jonas Brånalt, Ingemar Kvarnström, Björn Classon, Bertil Samuelsson, Ulrika Nillroth, U.Helena Danielson, Anders Karlén, Anders Hallberg

Journal:

Tetrahedron Letters

Year:

1997

Language:

english

File:

PDF, 206 KB

english, 1997

19

Synthesis of Potential Thrombin Inhibitors. Incorporation of Tartaric Acid Templates as P2 Proline Mimetics

Anders Dahlgren, Jonas Brånalt, Ingemar Kvarnström, Ingemar Nilsson, Djordje Musil, Bertil Samuelsson

Journal:

Bioorganic & Medicinal Chemistry

Year:

2002

Language:

english

File:

PDF, 340 KB

english, 2002

20

Novel Morpholinone-Based d-Phe-Pro-Arg Mimics as Potential Thrombin Inhibitors: Design, Synthesis, and X-ray Crystal Structure of an Enzyme Inhibitor Complex

Anders Dahlgren, Per-Ola Johansson, Ingemar Kvarnström, Djordje Musil, Ingemar Nilsson, Bertil Samuelsson

Journal:

Bioorganic & Medicinal Chemistry

Year:

2002

Language:

english

File:

PDF, 303 KB

english, 2002

21

Synthesis of 2′,3′-Didehydro-2′,3′-Dideoxy-3′-C-Methyl Substituted Nucleosides

Ioannidis, Panagiotis, Classon, Björn, Samuelssony, Bertil, Kvarnström, Ingemar

Journal:

Nucleosides and Nucleotides

Year:

1993

Language:

english

File:

PDF, 801 KB

english, 1993

22

Synthesis of Novel Isothionucleosides as Potential Antiviral Agents

Jonas Brånalt, Gunilla Niklasson, Ingemar Kvarnström, Björn Classon, Bertil Samuelsson

Journal:

Molecules Online

Year:

1998

Language:

english

File:

PDF, 128 KB

english, 1998

23

Syntheses of O -(2-Acetamido-2-Deoxy-α-D-Galactopyranosyl)- Myo -Inositols

Alenfalk, Susanne, Kvarnström, Ingemar, Niklasson, Annika, Niklasson, Gunilla, Svensson, Stefan C. T., Garegg, Per J.

Journal:

Journal of Carbohydrate Chemistry

Year:

1991

Language:

english

File:

PDF, 530 KB

english, 1991

24

Synthesis of Novel Thrombin Inhibitors. Use of Ring-Closing Metathesis Reactions for Synthesis of P2 Cyclopentene- and Cyclohexenedicarboxylic Acid Derivatives

Thorstensson, Fredrik, Kvarnström, Ingemar, Musil, Djordje, Nilsson, Ingemar, Samuelsson, Bertil

Journal:

Journal of Medicinal Chemistry

Year:

2003

Language:

english

File:

PDF, 492 KB

english, 2003

25

Synthesis of C 2 Symmetric Potential Inhibitors of HIV-1 Protease From D-Mannitol

Niklasson, Gunilla, Kvarnström, Ingemar, Classon, Björn, Samuelsson†, Bertil, Nillroth, Ulrika, Danielson, Helena, Karlén, Anders, Hallberg, Anders

Journal:

Journal of Carbohydrate Chemistry

Year:

1996

Language:

english

File:

PDF, 725 KB

english, 1996

26

Novel potent macrocyclic inhibitors of the hepatitis C virus NS3 protease: Use of cyclopentane and cyclopentene P2-motifs

Marcus Bäck, Per-Ola Johansson, Fredrik Wångsell, Fredrik Thorstensson, Ingemar Kvarnström, Susana Ayesa, Horst Wähling, Mikael Pelcman, Katarina Jansson, Stefan Lindström, Hans Wallberg, Björn Classo

Journal:

Bioorganic & Medicinal Chemistry

Year:

2007

Language:

english

File:

PDF, 506 KB

english, 2007

27

Synthesis of some benzyl and methyl ethers of myo-inositol

Per J. Garegg, Bengt Lindberg, Ingemar Kvarnström, Stefan C.T. Svensson

Journal:

Carbohydrate Research

Year:

1988

Language:

english

File:

PDF, 834 KB

english, 1988

28

Synthesis of Some 2′,3′-Dideoxy-3′-C-Fluoromethyl and 3′-C-Azidomethyl Nucleosides

Svansson, Lars, Kvarnström, Ingemar, Classon, Björn, Samuelsson, Bertil

Journal:

Nucleosides and Nucleotides

Year:

1992

Language:

english

File:

PDF, 760 KB

english, 1992

29

HIV-1 Protease Inhibitors Based on Acyclic Carbohydrates

Zuccarello, Guido, Bouzide, Abderrahim, Kvarnström, Ingemar, Niklasson, Gunilla, Svensson, Stefan C. T., Brisander, Magnus, Danielsson, Helena, Nillroth, Ulrika, Karlén, Anders, Hallberg, Anders, Clas

Journal:

Journal of Organic Chemistry

Year:

1998

Language:

english

File:

PDF, 309 KB

english, 1998

30

Solid phase assisted synthesis of HIV-1 protease inhibitors. Expedient entry to unsymmetrical substitution of a C 2 symmetric template

Oscarsson, Karin, Classon, Björn, Kvarnström, Ingemar, Hallberg, Anders, Samuelsson, Bertil

Journal:

Canadian Journal of Chemistry

Year:

2000

File:

PDF, 339 KB

2000

31

Novel glycosylation reagents: synthesis of disaccharides containing 2-deoxy-2-iodo-α-d-talopyranosyl groups

Per J. Garegg, Bertil Samuelsson, Peter Konradsson, Ingemar Kvarnström, Stefan C.T. Svensson

Journal:

Carbohydrate Research

Year:

1981

Language:

english

File:

PDF, 216 KB

english, 1981

32

Synthesis and SAR of Thrombin Inhibitors Incorporating a Novel 4-Amino-Morpholinone Scaffold: Analysis of X-ray Crystal Structure of Enzyme Inhibitor Complex

Nilsson, Jonas W., Kvarnström, Ingemar, Musil, Djordje, Nilsson, Ingemar, Samulesson, Bertil

Journal:

Journal of Medicinal Chemistry

Year:

2003

Language:

english

File:

PDF, 636 KB

english, 2003

33

Inhibitors of the C 2 -Symmetric HIV-1 Protease: Nonsymmetric Binding of a Symmetric Cyclic Sulfamide with Ketoxime Groups in the P2/P2‘ Side Chains

Hultén, Johan, Andersson, Hans O., Schaal, Wesley, Danielson, Helena U., Classon, Björn, Kvarnström, Ingemar, Karlén, Anders, Unge, Torsten, Samuelsson, Bertil, Hallberg, Anders

Journal:

Journal of Medicinal Chemistry

Year:

1999

Language:

english

File:

PDF, 317 KB

english, 1999

34

Design and Synthesis of Potent C 2 -Symmetric Diol-Based HIV-1 Protease Inhibitors: Effects of Fluoro Substitution

Pyring, David, Lindberg, Jimmy, Rosenquist, Åsa, Zuccarello, Guido, Kvarnström, Ingemar, Zhang, Hong, Vrang, Lotta, Unge, Torsten, Classon, Bjorn, Hallberg, Anders, Samuelsson, Bertil

Journal:

Journal of Medicinal Chemistry

Year:

2001

Language:

english

File:

PDF, 138 KB

english, 2001

35

Hydrolysis of glycosides under reducing conditions

Per J. Garegg, Bengt Lindberg, Peter Konradsson, Ingemar Kvarnström

Journal:

Carbohydrate Research

Year:

1988

Language:

english

File:

PDF, 284 KB

english, 1988

36

Symmetric fluoro-substituted diol-based HIV protease inhibitors : Ortho-fluorinated and meta-fluorinated P1/P1′-benzyloxy side groups significantly improve the antiviral activity and preserve binding efficacy

Jimmy Lindberg, David Pyring, Seved Löwgren, Åsa Rosenquist, Guido Zuccarello, Ingemar Kvarnström, Hong Zhang, Lotta Vrang, Björn Classon, Anders Hallberg, Bertil Samuelsson, Torsten Unge

Journal:

Year:

2004

Language:

english

File:

PDF, 336 KB

english, 2004

37

Design and Synthesis of Potent Inhibitors of Plasmepsin I and II: X-ray Crystal Structure of Inhibitor in Complex with Plasmepsin II

Johansson, Per-Ola, Lindberg, Jimmy, Blackman, Michael J., Kvarnström, Ingemar, Vrang, Lotta, Hamelink, Elizabeth, Hallberg, Anders, Rosenquist, Åsa, Samuelsson, Bertil

Journal:

Journal of Medicinal Chemistry

Year:

2005

Language:

english

File:

PDF, 334 KB

english, 2005

38

Synthesis of enantiomerically pure cis and trans 2-aminocyclopentanecarboxylic acids. Use of proline replacements in potential HIV-protease inhibitors

Daniel Nöteberg, Jonas Brånalt, Ingemar Kvarnström, Björn Classon, Bertil Samuelsson, Ulrika Nillroth, U.Helena Danielson, Anders Karlén, Anders Hallberg

Journal:

Year:

1997

Language:

english

File:

PDF, 585 KB

english, 1997

39

Synthesis of Mimics to Thymidine Triphosphate and 3′-Deoxy-3′-fluorothymidine Triphosphate

Björsne, Magnus, Classon, Björn, Kvarnström, Ingemar, Samuelsson, Bertil

Journal:

Nucleosides and Nucleotides

Year:

1993

Language:

english

File:

PDF, 541 KB

english, 1993

40

Synthesis of 2′,3′-Didehydro-2′,3′-dideoxy-2′- C -methylsubstituted Nucleosides Using a Novel S N 2′ Type Reaction

Ioannidis, Panagiotis, Classon, Björn, Samuelsson, Bertil, Kvarnström, Ingemar

Journal:

Nucleosides and Nucleotides

Year:

1993

Language:

english

File:

PDF, 828 KB

english, 1993

41

Synthesis of carbocyclic 2′3′-dideoxy-2′-fluoro-3′-C-hydroxymethyl nucleoside analogues as potential inhibitors of HIV and HSV

Johanna Wachtmeister, Classon Björn, Samuelsson Bertil, Ingemar Kvarnström

Journal:

Year:

1997

Language:

english

File:

PDF, 872 KB

english, 1997

42

[Part 2: Biological Sciences] || Immunochemical Determination of the Configuration of a Haptenic Substituent

Michael Heidelberger, Ingemar Kvarnstrom, Jorunn Eriksen, Wolfgang Nimmich and William F. Dudman

Journal:

Proceedings of the National Academy of Sciences

Year:

1980

Language:

english

File:

PDF, 349 KB

english, 1980

43

Synthesis of Some 2′,3′-Dideoxy-2′-C-Methyl-Substituted Nucleosides

Ioannidis, Panagiotis, Classon, Björn, Samuelsson, Bertil, Kvarnström, Ingemar

Journal:

Nucleosides and Nucleotides

Year:

1992

Language:

english

File:

PDF, 694 KB

english, 1992

44

Synthesis of [4,5-Bis(hydroxymethyl)-1,3-dithiolan-2-yl]nucleosides as Potential Inhibitors of HIV 1

Brånalt, Jonas, Kvarnström, Ingemar, Classon, Björn, Samuelsson, Bertil

Journal:

Journal of Organic Chemistry

Year:

1996

Language:

english

File:

PDF, 186 KB

english, 1996

45

Synthesis of Novel Olefinic Carbocyclic Purine Nucleoside Analogues

Wachtmeister, Johanna, Classon, Bjorn, Samuelsson, Bertil, Kvarnström, Ingemar

Journal:

Nucleosides Nucleotides & Nucleic Acids

Year:

1995

Language:

english

File:

PDF, 189 KB

english, 1995

46

Synthesis of Some Purine Carbocyclic Isosteres of 2′,3′-Dideoxy-3′-C-Hydroxymethyl Nucleosides as Potential Inhibitors of HIV

Janson, Marianne, Svansson, Lars, Svensson, Stefan C. T., Kvarnström, Ingemar, Classon, Björn, Samuelsson, Bertil

Journal:

Nucleosides and Nucleotides

Year:

1992

Language:

english

File:

PDF, 571 KB

english, 1992

47

Synthesis of 2′,3′-dideoxy-3′,4′-dihydroxymethyl substituted pyrimidine nucleoside analogues

Magnus Björsne, Björn Classon, Inger Kers, Bertil Samuelsson, Ingemar Kvarnström

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1995

Language:

english

File:

PDF, 165 KB

english, 1995

48

Synthesis of 1D-2-O- and 1D-5-O-(α-D-galactopyranosyl)-4-O-methyl-chiro-inositol: preference for equatorial hydroxyl groups in the imidate galactosylation procedure

Per J. Garegg, Ingemar Kvarnström

Journal:

Carbohydrate Research

Year:

1981

Language:

english

File:

PDF, 539 KB

english, 1981

49

Configuration of the acetal carbon atom of pyruvic acid acetals in some bacterial polysaccharides

Per J. Garegg, Per-Erik Jansson, Bengt Lindberg, Frank Lindh, Jörgen Lönngren, Ingemar Kvarnström, Wolfgang Nimmich

Journal:

Carbohydrate Research

Year:

1980

Language:

english

File:

PDF, 403 KB

english, 1980

50

Detection of staphylococcus aureus infection by enzyme-linked immunosorbent assay and immunoblotting, using high molecular weight staphylococcal proteins

Cecilia Rydén, Alia Yacoub, Ann Kvarnström, Torkel Wadström, Ingemar Maxe, Göran Friman, Kristofer Rubin

Journal:

FEMS Microbiology Letters

Year:

1990

Language:

english

File:

PDF, 633 KB

english, 1990

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